Specifying Offline File Folder Location

I’m trying to get things back online and organized on my laptop for working with clients. One of the things I used to do is have many of the frequently used files for clients set to be available offline when I’m disconnected from our network.

The problem was that I quickly ran out of available free space on my hard drive to maintain all the files I may need along with those programs and options that are run locally from the machine all the time.

Here’s my question, can I easily redirect and RELY on moving my default offline files location to my portable, Western Digital 250GB USB drive?

Obviously this is my work machine and it needs to be reliable and no major unexpected issues arise when I’m not expecting them.